Photo of Brice


Phone: + 33 1 44 27 45 87
Email: brice.hoffmann [at] impmc.upmc [dot] fr

I am a postdoc at University Pierre et Marie Curie, Paris 6, France, in Bioinformatics (Docking, Virtual Screening). My research is funded by the French cystic fibrosis foundation Vaincre La Mucoviscidose ( The aim of our project is to develop pharmacological therapeutics targeting the roots of the disease, based on original 3D models of the CFTR protein. I am involved in the identification and characterization of small molecules which could act as modulators and/or correctors using bioinformatics (docking, virtual screening).


Postdoc in Computational Biology

UPMC, Paris, Since 2012

  • Molecular dynamics simulation and virtual screening of CFTR
  • funded by French cystic fibrosis association Vaincre la Mucoviscidose
  • Supervisor: Isabelle Callebaut

PhD in Bioinformatics Mines ParisTech, Fontainebleau, 2007 to 2012

  • Subject: Prediction of protein-ligand interactions using novel chemogenomic methods combining the approaches based on the structures and based on the ligands. Click here to see the final version of my PhD thesis
  • Supervisors: Veronique Stoven, Jean-Philippe Vert

Internship in Molecular modelisationINRA, Jouy-en-Josas, 2007

  • Homology modeling of GPCR-like proteins, energy minimization and docking
  • Skills gained: problem identification and solving, self-initiative, reporting
Teaching Assistance

Molecular modelisation and dockingUniv. Paris and Versailles 2009

  • Practical session, 52 hours
  • Skills gained: communication, presenting

Postgraduate degree in BioinformaticsUniv. Versailles, 2006-2007

Master's degree in GeneticsUniv. Evry, 2005-2006

Bachelor's degree in BiochemistryUniv. Orleans, 2002-2005


Docking, Modelisation

Autodock, OpenEye, FlexX, DOCK, Modeller, NAMD, VMD, Chemaxon

Languages, Platforms

Perl, Python, C, Latex, Mac, Unix, Windows

Moelcular biology

Protein/DNA extraction, PCR, electrophoresis, blotting, chromatography

Cell biology

Cell culture, microscopy, cell cycle analysis, transfection and expression of plasmid DNA in plant cells

  • A new protein binding pocket similarity measure based on comparison of clouds of atoms in 3d: application to ligand prediction. BMC Bioinformatics, 11(1):99, 2010. Click here to see the article.
  • Virtual screening of GPCRs: an in silico chemogenomics approach. BMC Bioinformatics, 9:363, 2008. Click here to see the article.
  • Human genetic polymorphisms in t1r1 and t1r3 taste receptor subunits affect their function. Chem Senses, 36(6):527, Jul 2011. Click here to see the article.
Available on request